Dec 6

Dr. Isabelle Aubert, Associate Professor, University of Toronto; Senior Scientist, Sunnybrook Research Institute 

Targeting cholinergic neurons, neurogenesis and amyloid-beta in animal models of Alzheimer's disease.  

Learning objectives:

(1) Review some of the challenges with current treatments for Alzheimer's disease

(2) Gain knowledge on possible new therapeutic approaches related to cholinergic neurons and adult neurogenesis

(3) Consider the potential of MRI-guided focused ultrasound for the delivery of therapeutics to the brain

Dec 13

 Dr. Philip Marsden, MD, FRCPC, Professor of Medicine, Keenan Chair in Medical Research at St Michael’s Hospital

Oreopoulos-Baxter Division Director of Nephrology at the University of Toronto

Physician’s guide to the human genome

Learning objectives:

(1) Summarize the human genome project circa 2003

(2) Describe advances since 2003 in understanding human genetic diversity

(3) Explain how common and rare genetic variants are relevant in disease management

(4) Introduce how epigenetics is relevant to understanding the genome

Christmas

Break

Rounds resume on January 10, 2012.